Why does Waardenburg happen?
causes. Waardenburg syndrome is most often inherited as an autosomal dominant trait. This means that only one parent needs to pass on the defective gene for a child to be affected.
Which gene causes Waardenburg syndrome? Mutations in the EDN3, EDNRB, MITF, PAX3, and SOX10 genes cause Waardenburg syndrome. Read also : What are the 9 kind of martial arts?. In dominant disorders, a single copy of the disease gene (received from the mother or father) will be expressed by “dominating” the other normal gene, potentially resulting in the onset of the disease.
What are the four types of Waardenburg syndrome?
There are four main types of Waardenburg syndrome. The most common are type I and type II. Read also : What are the 8 martial arts?. Type III (Klein-Waardenburg syndrome) and type IV (Waardenburg-Shah syndrome) are rarer. The multiple types of this syndrome result from defects in different genes.
What is type 4 Waardenburg syndrome? Type 4 Waardenburg syndrome, also known as Waardenburg-Shah syndrome, is a genetic condition that can cause hearing loss; changes in the coloring (pigmentation) of hair, skin and eyes; and Hirschsprung’s disease, a bowel disorder that causes severe constipation or a blockage of the bowel.